Derrick Henry’s power meets Buffalo’s young interior in a Sunday night showdown with Baltimore. Henry’s size-speed blend keeps Buffalo’s rookie tackles TJ Sanders and Deone Walker honest as Baltimore leans on the offensive line to create lanes and leverage. Baltimore’s offense, spearheaded by Lamar Jackson, can threaten you with downhill runs or spread you out, forcing Buffalo to swarm and scrape to the ball. Terrel Bernard, Matt Milano, and Taylor Rapp anchor Buffalo’s run defense, with Cole Bishop stepping in as a versatile rover behind them.

Buffalo’s challenge is real: Henry has posted massive yardage behind strong lines before, and Baltimore’s scheme can flip tempo at a moment’s notice. Buffalo counters with veteran leadership and a dynamic secondary that must ride run fits and communication, especially against play-action and misdirection. The night should tilt toward disciplined gaps and active pursuit, with Henry poised to influence fantasy lineups through volume and goal-line appearances despite the Bills’ best efforts to limit him.

Week 1 fantasy preview kicks off with Cowboys vs Eagles on Thursday and Chiefs vs Chargers in Sao Paulo, pairing top-tier quarterback play with big-play ceilings across WRs and RBs. Josh Allen sits down for a Bills chat ahead of Bills-Ravens, anchoring a slate that also features Steelers-Jets and Lions-Packers as potential week-opening breakout opportunities. The episode leans into matchup-driven angles, red-zone usage, and early-season trends to shape early lineup and DFS decisions.

Expect emphasis on pass-heavy offenses, early snap splits, and risk-reward play in high-profile tilts, plus sleepers who could emerge with increased roles in Week 1. Narrative momentum around New York’s Rodgers era and the Packers’ retooled offense adds another layer for fantasy managers plotting rosters and stacks this opening weekend.

Bills and Ravens unveil Week 1 injury reports ahead of Sunday Night Football at Highmark Stadium. Bills: Tyler Bass (hip/groin) did not practice; Elijah Moore (personal) listed; Tre'Davious White (groin) limited; Keon Coleman (groin) limited; Christian Benford (groin) full; Khalil Shakir (ankle) limited. Ravens: Isiah Likely (foot) did not practice; Patrick Richard (calf) limited; Jaire Alexander (knee) limited; Daniel Faalele (illness) limited.

Fantasy managers should monitor practice statuses closely. If Shakir, Coleman, or White are limited, Elijah Moore could lead Bills targets; Bills’ secondary depth could shift with White’s status. For Ravens, Likely’s status will influence TE usage in Week 1; with Alexander possibly limited, Bills’ aerial attack could exploit matchup edges. Kicking and field-goal dynamics also hinge on Bass and the health of the kicking unit.

Allen headlines Week 1 with MVP buzz and a BR nod as the top QB, facing a Ravens defense that blends size and discipline. Expect Buffalo to lean on Allen’s rushing upside and big-play passing to set a ceiling, even in a tough matchup. Cook and Davis are projected to share carries behind a formidable front, with Cook’s red-zone punch and Davis as a potential change-of-pace option. Shakir and Kincaid factor as Buffalo’s primary pass-game weapons, while Baltimore’s aerial defense remains a test.

Buffalo’s run game is unlikely to erase the challenge from Baltimore’s front, and the Jaguars’ passing-yard pace last season hints at seams to exploit if Buffalo stays patient with play-action and tempo. Allen’s Week 1 floor remains high thanks to rushing TD upside and authoritative target distribution to Shakir, Kincaid, and the Bills’ receiving corps. Fantasy managers should price Allen as a high-ceiling anchor, with Shakir and Kincaid as upside depending on game flow and Ravens’ coverage.