Anthony Richardson exited Indianapolis’ preseason opener after a sack by David Ojabo, injuring his right hand and handing the reins the rest of the night to Daniel Jones. The moment underscored a troubling pattern for Richardson, who has battled injuries in each of his two NFL seasons. Draft Sharks’ durability score pegs him at 2.3 out of 5 with roughly a 40% chance of another injury in 2025, elevating the stakes for Colts pass-catchers and weekly plan ahead of Week 1.

If Richardson misses time, Indianapolis could pivot to a run-first rhythm and lean on a patchwork offensive line, potentially muting upside for fantasy-relevant targets. The hand injury adds to a portfolio of previous absences, including a concussion and various sprains, intensifying questions about week-to-week availability and how much initial usage the Colts will allocate to Richardson when he’s healthy again.

Owners should monitor official status updates closely, because a setback could shift early-season projections for Pittman, Granson, and the receiving corps. In the meantime, fantasy managers might reassess risk-reward, weighing Richardson’s ceiling against the likelihood of missed time and how a backup QB performance could tilt offensive efficiency and target distribution in Colts games.

Overall, the incident casts a sharper light on Richardson’s durability narrative and could influence how aggressively fantasy rosters invest in Colts pass-game pieces, especially if the rookie’s availability remains uncertain through early September drills.