Detroit travels to Baltimore for Monday Night Football after Week 2's surge, facing a Ravens offense led by Lamar Jackson with Derrick Henry, Zay Flowers and De'Andre Hopkins. Baltimore's run game and Jackson's mobility keep it dangerous, while Detroit's improved line and tackling try to slow them and force mistakes.

Key questions hinge on pass protection and edge pressure. If Detroit can disrupt Jackson and win upfront, this stays tight; Baltimore must protect Jackson and carve out long drives. For fantasy, lean Jackson and Flowers, with Hopkins as a value in deeper formats; the line sits Ravens -5.5 in a likely close one.

Buffalo marches into Week 3 riding a 2-0 start and a favorable three-game homestand that could set up a 3-0 sweep in the AFC East before a November test with Kansas City. James Cook’s 132-yard, two-TD day underscored a balanced attack, while Josh Allen managed an efficient performance without needing Superman-level numbers. The defense limited the Jets’ chances, keeping Buffalo in control and widening the gap in the division. For fantasy managers, Cook’s rising workload, continued rushing floor from Allen, and the Bills’ multi-faceted approach stand out as clear signals to prioritize Bills assets in the near term.

Buffalo’s path remains grounded in a ground-and-stop-the-run philosophy, with Trubisky providing a brief, supportive spark but not altering the core plan. The looming Week 3 clash with Miami adds a meaningful test, yet the overall setup favors Buffalo’s fantasy ceiling: Cook as a strong RB2 with upside, Allen’s rushing floor, and a defense that can win scenarios without heavy quarterback scoring.

Aaron Jones is out four weeks after going on IR with a hamstring injury, shifting major early-season workload to Jordan Mason in a new every-down role. Austin Ekeler is done for the year with an Achilles tear, leaving Washington Commanders’ backfield trio of Jacory Croskey-Merritt, Chris Rodriguez Jr., and Jeremy McNichols to absorb volume. Tyjae Spears could return in Week 5, giving Tennessee a much-needed boost behind Tony Pollard’s workload. Jaylen Wright is a strong bet to debut for Miami against Buffalo if cleared, while Rasheen Ali is sidelined by a concussion and Keaton Mitchell looms as the Ravens’ next specialist option. Kyle Juszczyk’s concussion further thins San Francisco’s blocking defense, joining George Kittle and Brock Purdy on the injury report. In short, backfields across the league are in flux heading into Week 3.

Specify your lineups with an eye on pass-catching upside and changing handcuff dynamics: Mason for immediate RB2–flex value, Croskey-Merritt and Rodriguez Jr. sharing volume in Ekeler’s absence, and Mitchell nudging into meaningful snaps if Ali remains out. Spear’s return would immediately restore Titans’ backfield depth, while Wright’s status could unlock Dolphins’ late-week upside against Buffalo for fantasy rosters in need of a boost.

Week 3 fantasy angles hinge on Miami’s De'Von Achane versus a Bills run defense dealing with interior disruption. Buffalo hosts the Dolphins as 12-point favorites, but Oliver’s ankle injury could widen gaps for Achane, boosting his fantasy ceiling. A Detroit–Baltimore shoot-window also looms, with both offenses poised for explosive passing. Premium analytics tools and prop bets loom large for lineup decisions and in-season bets.

The Cincinnati Bengals are shoring up quarterback depth behind Jake Browning. After adding Brett Rypien to the 53-man roster, Cincinnati signed Mike White and Sean Clifford to the practice squad, but none are proven starters. The club is weighing several external options—Malik Willis from Green Bay, Jameis Winston from New York, Will Grier from Dallas, and Tyler Huntley from Baltimore—while also considering pricier veteran routes and speculative fits like Kirk Cousins or Giants’ Russell Wilson/Jaxson Dart. Goal: solid insurance at a low cost, not a Browning upgrade.