Saints-Jaguars and Bills-Bears close the NFL preseason Week 2 slate, with Trevor Lawrence slated to start for Jacksonville and Caleb Williams set to lead Chicago briefly, while Jacksonville rookie Travis Hunter is listed questionable for action. The betting edge centers on New Orleans as a 1.5-point underdog and the Under in the Saints-Jaguars matchup, along with a Bears-first-half spread play against Buffalo and the Under in Bears-Bills. The tone around the Sunday bets emphasizes fading inflated preseason totals, leveraging coaching debuts, and maximizing value from backup QBs and rookies who are squarely in fantasy-relevant roles.

Across the scale, Josh Allen won’t play for Buffalo, nudging the Bills’ offensive rhythm toward backups and limiting high-scoring ceiling in Week 2 action. Chicago’s early snaps feature Williams and veteran Keenum in the mix, while New Orleans leans on Spencer Rattler’s experience to stabilize a roster that fantasy owners will watch closely for potential sleeper performances. The overarching theme: exploit first-half dynamics, watch for injuries, and lean into savvy under bets as public totals stay inflated ahead of final rosters.

For fantasy strategists, it’s about pinpointing value from starting minutes, the interplay of starter absence, and the emergence of in-game game-scripts that could translate into DFS upside for secondary options and rookies who earn snaps in this tune-up environment.

Matthew Stafford’s back issue has shifted from concerning to alarming as he sits out camp with an aggravated disc. The 37-year-old has not practiced, and Week 1’s status remains officially uncertain. Los Angeles is weighing a quarterback addition to shield the offense, with Jimmy Garoppolo and Stetson Bennett in the pipeline behind him. The three most plausible add-ons are Brett Rypien, Trevor Siemian, and Case Keenum, each bringing a different blend of experience and familiarity with the Rams’ system.

Brett Rypien, who already knows Sean McVay’s scheme, could serve as a steady emergency veteran who isn’t a liability to injury. Trevor Siemian offers long-running starter pedigree and the comfort of Brian Callahan’s offense, while Case Keenum remains a credible veteran backup with 33 NFL starts since 2015. The Rams would likely pounce if Keenum becomes available, given his track record and NFC familiarity. The looming question: can one of these veterans stabilize LA’s quarterback room enough to keep the offense humming while Stafford heals?

Buffalo and Chicago square off in Week 2 of the NFL preseason with a nationally televised tilt that features a familiar exchange of quarterbacks and roster depth. The 8 p.m. ET kickoff marks Buffalo’s aim to rebound after a 34-25 loss in which Mitch Trubisky topped the Bills’ passing chart, returning to Chicago for joint practices against his former club. Chicago counterpoints with Case Keenum, who produced two touchdowns in their opener as they evaluate backup QB depth ahead of the regular season. The game will also give Mike White and Shane Buechele extended looks for Buffalo behind Josh Allen, testing the back end of the depth chart. Fox broadcast the game locally in Buffalo and Chicago, with NFL+ and Fubo offering streaming options. This matchup isn’t about Week 1 fantasy implications, but it’s a valuable barometer for how teams distribute reps and which players could emerge as sleepers or post-draft adds in deeper leagues.

Trubisky’s return to the Bears puts a spotlight on how Buffalo leverages its clipboard-holdovers and how Chicago prints its depth chart behind Keenum. Buffalo will likely rotate third- and fourth-string reps, while Chicago’s veteran presence could tilt the pace of the game for fantasy managers watching for late-round or dynasty implications. The setting—Soldier Field for a final warmup before regular-season action—adds a narrative edge to a game that will be watched closely by fantasy enthusiasts as a gauge for who might step into meaningful roles in late summer.

Miami’s QB depth shined a light on fantasy risk and upside as the Dolphins pressed through a multi-signal-caller look, led by Tua Tagovailoa, with Quinn Ewers and Zach Wilson mixing in. On the other side, Chicago rolled through Tyson Bagent, Case Keenum and Austin Reed, highlighting the Bears’ unsettled QB puzzle and potential late-season fantasy implications for back-end rosters. Caleb Williams looms as a college-adjacent storyline that coaches used to spark dialogue about development and long-term plans. The sand in the hourglass for both teams shows a QB carousel that could shape waiver priorities and dynasty leverage all season.

In practice terms, Tagovailoa maintains top fantasy trust, while Ewers remains a watchful hold in dynasty or 2QB formats, given a rough debut and the dolphins’ rotating approach. Wilson’s presence adds speculative depth for owners chasing late-round upside or trades. Reed’s appearance trims the Bears’ ceiling for immediate value but signals a broader evaluation window for Chicago’s passing game. Overall, this game underscores how preseason QB tinkering can tilt early-season depth charts and fantasy risk-reward in meaningful ways.

Tua Tagovailoa opened Miami’s preseason drive with clean efficiency, finishing 5-of-6 for 27 yards as the Dolphins moved 15 plays against Chicago’s backups. A Bears goal-line stand kept Miami from scoring on its first possession, but the night belonged to the QB depth charts, with Zach Wilson and Quinn Ewers delivering three straight TD drives and a 56-yard field goal by Jason Sanders to tie the game late at 24.

Chicago’s defense dominated Johnson’s debut, racking six sacks, including three by Austin Booker, and forcing a turnover on a strip-sack near the goal line that set up a Keenum-to-Hankins TD. Ewers connected on a 21-yard play to Mattison and a late score by rookie Ollie Gordon to swing the lead, while Wilson came back to connect with Nick Westbrook-Ikhine and Tahj Washington for sustained drives. The showcase elevated depth-chart chatter and fantasy optimism for Miami’s backup quarterbacks.