Jefferson's Week 1 status is pivotal after a preseason hamstring kept him out in August. Minnesota expects him to play Monday against Chicago, making him the focal point of the Vikings' aerial attack.

If Jefferson is limited or inactive, Jalen Nailor and Adam Thielen become the Week 1 options for Minnesota, while Chicago could lean on Luther Burden III and, in deeper leagues, Olamide Zaccheaus. Fantasy managers should monitor reports and be ready to pivot as the game plan unfolds.