Week 2 fantasy decisions center on high-profile wideouts and how injuries, matchups, and QB play shape ceilings. Pittman Jr. may see fewer targets against Denver’s Patrick Surtain II despite practicing; Waddle’s shoulder adds risk against New England if he suits up, while Jameson Williams could benefit from a softer Week 2 matchup with Chicago. Rome Odunze emerged as Caleb Williams’ favorite target early, Marvin Harrison Jr. faces Jaycee Horn’s shadow in a tough Week 2 tilt, and Olave, DeVonta Smith, Diggs, Zay Flowers, and Jeudy are all in the crosshairs of tough lineup calls. The Who Should I Start tool remains the quick path to a confidence-booster, letting you compare up to four players with format-aware projections and up-to-date news.

In short, Week 2 starts hinge on health plus matchup nuance: Lions WRs versus Detroit’s pass-friendly defense, Panthers’ cornerback matchups for Harrison Jr., and the ever-present WR1/WR2 balance in Philadelphia and Buffalo. The piece also highlights the tool’s improvements—tiles, bye-week awareness, and scoring-format options—so fantasy managers can build stronger, data-driven lineups in real time.