Buffalo at Chicago in primetime Week 2 of the preseason hinges on depth-chart theater more than box-score glamour. Mitch Trubisky is slated as QB2 with the job to lose, and the night offers a clear chance to prove pocket poise and smart decision-making against his former club. Curtis Samuel and Elijah Moore stand out as potential breakout plays if healthy, with Moore especially positioned to seize a prominent role amid a thinner Bills WR corps. On defense, Buffalo looks to rookies Deone Walker and TJ Sanders to stack meaningful snaps, while Ed Oliver, DaQuan Jones and Larry Ogunjobi push the interior, and Tre’Von Edmunds squanders no opportunity against his old teammates. The safety group—Damar Hamlin, Taylor Rapp, and Cole Bishop—needs reps to validate Babich’s plans, with Samuel’s status adding another layer of intrigue.