Saints-Jaguars and Bills-Bears close the NFL preseason Week 2 slate, with Trevor Lawrence slated to start for Jacksonville and Caleb Williams set to lead Chicago briefly, while Jacksonville rookie Travis Hunter is listed questionable for action. The betting edge centers on New Orleans as a 1.5-point underdog and the Under in the Saints-Jaguars matchup, along with a Bears-first-half spread play against Buffalo and the Under in Bears-Bills. The tone around the Sunday bets emphasizes fading inflated preseason totals, leveraging coaching debuts, and maximizing value from backup QBs and rookies who are squarely in fantasy-relevant roles.

Across the scale, Josh Allen won’t play for Buffalo, nudging the Bills’ offensive rhythm toward backups and limiting high-scoring ceiling in Week 2 action. Chicago’s early snaps feature Williams and veteran Keenum in the mix, while New Orleans leans on Spencer Rattler’s experience to stabilize a roster that fantasy owners will watch closely for potential sleeper performances. The overarching theme: exploit first-half dynamics, watch for injuries, and lean into savvy under bets as public totals stay inflated ahead of final rosters.

For fantasy strategists, it’s about pinpointing value from starting minutes, the interplay of starter absence, and the emergence of in-game game-scripts that could translate into DFS upside for secondary options and rookies who earn snaps in this tune-up environment.