Breakout RB chatter anchors fantasy talk as a fresh class eyes 2025. Chase Brown and Bucky Irving loom as the clearest two-round targets in CIN and TB, with sustained midseason roles likely. Kenneth Walker III remains the safest floor in Seattle’s backfield, while Trayvon Henderson in New England presents a high-upside path if nurses pass-game usage and goal-line work. Jordan Mason could emerge in San Francisco’s multi-back system, and Tank Bigsby sits as a ceiling-rich lotto ticket in Jacksonville. Jaylen Warren and Roschon Johnson—plus Caleb Johnson in CLE—provide late-round upside as backfields scatter touches. The conversation threads through offensive schemes, health risk, and the slice of receiving work these rookies could seize as the season unfolds.