Fred Warner’s season-ending ankle injury compounds a 49ers defense already ravaged by Nick Bosa’s torn ACL, with Purdy, Kittle and Aiyuk also dinged. Ji’Ayir Brown is thrust into bigger duties as the defense retools, while Tampa Bay’s Rachaad White keeps the Buccaneers’ ground game rolling. Jauan Jennings battled through five broken ribs and ankle sprains in Week 6. The ripple effects hit fantasy lineups and defensive metrics, reshaping upcoming matchups for SF and TB.

Expect the 49ers to lean on younger linebackers and scheming to mitigate the loss, while Brown and others in the depth chart get increased exposure in IDP formats. Bosa’s absence compounds the pass rush and run defense strain, making matchup-specific projections more volatile for the SF defense and elevating the value of opposing offenses against them.

Fred Warner suffered a dislocated ankle against Tampa Bay, heading toward surgery and ending his season. The injury compounds San Francisco’s woes after Nick Bosa’s earlier absence, leaving the 49ers thin at a position that anchors run defense and pass coverage. Warner’s leadership loss is a seismic blow as the defense eyes a potential depth-filled season downgrade.

Kyle Shanahan stressed the need for the next man up, naming Tatum Bethune as the immediate catalyst to steady the middle. San Francisco fell to 4-2 in a 30-19 defeat, pressing a reshaped unit to adapt quickly and protect fantasy-friendly matchups as it leans more on depth and cohesion.

Week 6 pivots around Stafford, White, Prescott as prime starts with upside in favorable matchups, while Henry, Higgins, and Goff sit for safer floors or tougher games. The waiver wire heats up with top TE, WR, and RB adds set to reshape rosters, and the SNF slate features Lions at Chiefs with heavy narrative and potential edge-rusher moves for the 49ers. Jacobs weighs in on the win over Bengals as Chiefs-Lions prime-time drama looms, driving strategy for both lineups and DFS builds.

Week 6 fantasy notes crown Stafford, White, and Prescott as trustworthy starts, while Henry, Higgins, and Goff sit for tougher matchups. Buy-low and sell-high chatter sharpens trades and buys on the waiver wire, with specific top TE, WR, and RB adds to target before Week 6. The slate spotlights Lions at Chiefs, with KC’s discipline and the Bengals-Packers clash drawing attention for DFS and season-long rosters. Jacobs weighs in on a Raiders win over Cincinnati, underscoring offensive momentum.

Waiver priorities lean tight ends, then wide receivers and running backs to capitalize on Week 6 opportunities. Expect high-volume games from the QB trio in smart spot games, while monitoring lineup pivots from the 49ers, Chiefs, and Packers in the late-season push. A balanced mix of floor plays and upside picks defines the come-week strategy.