Philadelphia opens title defense against Dallas in the 2025 NFL Kickoff Game at Lincoln Financial Field. The defending champs went 14-3 and beat Kansas City in the Super Bowl; Dallas aims to rebound behind Dak Prescott with a healthier roster and new weapons. The line sits Eagles -7.5, total 47.5, and Prescott’s 243.5 passing yards prop draws attention. The SportsLine model simulations lean toward the Over and favor a side of the spread, setting up a fantasy-heavy, high-leverage Week 1 showdown for Hurts, Lamb, Pickens and company.