Five middle-round targets to chase in 2025 fantasy football are James Conner, Isiah Pacheco, Jordan Mason, Cam Skattebo, and Jaydon Blue. Conner sits as a dependable RB2 due to his steady production and strong involvement in the passing game, offering reliable weekly floor in New Arizona. Pacheco carries upside tied to continued mystique of the Chiefs’ high-octane offense, with improved pass-game usage and opportunity if health cooperates. Mason enters Minnesota’s backfield as a big, physical piece who could split carries in a committeelike run game, while Skattebo brings brutal efficiency and pass-catching ability that could unlock a late-season surge. Blue, a speedster in Dallas, enters a pass-heavy scheme with clear avenues to touches if he earns swings in the receiving game and screens. This group blends seasoned floors with high-ceiling bets, and their ADPs are spread enough to diversify risk across rounds 4–7.