Week 1 in Sao Paulo pairs Mahomes and the Chiefs with Herbert and the Chargers, a high-profile debut that could set the tone for fantasy grades in 2025. Mahomes is trending toward a deeper-pose attack after a preseason uptick in yards per attempt, while LAC leans into Harbaugh’s ground-and-pound framework with upgraded O-line and backfield depth. Several KC depth pieces are banged up (Norman-Lott questionable, Driskell out, Royals out), nudging Week 1 targets for the top trio in KC’s offense and shaping projected game flow.

DraftKings odds tilt KC (-166) with a 46.5 total, underscoring a close, competitive opener and a potential script toward late-game points. The Chargers carry a seven-game losing streak to KC but arrive healthier on both lines, making this a pivotal fantasy test across QB, RB and WR matchups. The narrative also weaves in one-score-game legacy and the wild-card history that colors expectations for both teams in Brazil.