Felix Anudike-Uzomah landed on injured reserve with a hamstring strain, likely ending his 2025 season for the Kansas City Chiefs. The 23-year-old former first-round pick has 41 tackles, 8 tackles for loss, and 3 sacks in 34 games since 2023, but injuries and limited snaps in 2024-25 have clouded his development. KC now leans on George Karlaftis, Charles Omenihu, and rookie Ashton Gillotte to fill edge depth, potentially elevating Gillotte into a regular early-role pass rusher as the team weighs a fifth-year option for 2027.

The injury backdrop intersects with a wider Chiefs storyline: Rashee Rice has drawn NFL attention with a report that a double-digit game suspension was proposed for him, which could shift targets and game plans while Anudike-Uzomah is sidelined. Fantasy managers should monitor the defensive rotation and Gillotte’s snaps, as well as how KC’s edge pressure and run defense evolve without their top pending breakout option. The development adds urgency to KC’s long-term decisions and could tilt depth-chart bets for the rest of the season.