Kansas City opens 2025 with six players on injured reserve or illness, led by Felix Anudike-Uzomah. Rookies Brandon George and Jake Briningstool also miss time, along with Deon Bush, Nazeeh Johnson and Janarius Robinson; Ethan Driskell remains on Reserve/Non-football Illness. KC must navigate roster moves to fill gaps, altering depth and early-season rotations without any of the IR group threatening a Week 1 starting role.