Nick Bolton's Week 2 status looms large for KC's defense. Bolton practiced fully after Week 1's biceps tweak, signaling a likely return against Philadelphia. If healthy, he stabilizes KC's run defense and pass rush; a miss would thrust Jack Cochrane into a bigger role with Jeffrey Bassa and Cooper McDonald ready to spell him. The Eagles pose a stern test, making Bolton's availability a top fantasy and betting concern.

Behind Bolton, KC's depth chart could be tested, but the Chiefs have capable backups who can slot in on limited snaps. The Week 2 rematch with the Super Bowl LIX rematch adds extra intrigue, as both sides lean on game-planning and depth to gain an edge in a pivotal early-season clash.