San Francisco stumbled 30-19 as injuries pile up and the defense buckles without Fred Warner. The offense never establishes footing behind a leaky line, while Kendrick Bourne shines with 142 receiving yards in a game where Jake Tonges steps up with 6 grabs. San Francisco’s run game stalls, and Kyle Shanahan is outmaneuvered by Todd Bowles’ blitzes. Eddy Pineiro nails all four field goals, yet Skyy Moore’s punt-return misadventures linger. A 4-2 start feels fragile as depth is tested.

With Kittle and Pearsall sidelined, the receiving group leans on Bourne, while Jauan Jennings battles through injuries and penalties. The defense can’t slow Baker Mayfield or shut down the run, and rookie Mykel Williams posts a first sack in a rough night. The focus shifts to roster adjustments and head-to-head coaching chess as the schedule tightens.