Looking ahead to the 2025 fantasy football season, the running back position is notably unpredictable, making it essential for managers to focus on the right tiered rankings. Saquon Barkley of the Philadelphia Eagles stands as the top running back, showcasing elite athleticism and the advantage of a dominant offensive line. Close behind are Christian McCaffrey of the San Francisco 49ers, who is expected to regain his form and dominate touches, and Bijan Robinson of the Atlanta Falcons, who had a breakout 2024 season.

Jahmyr Gibbs from the Detroit Lions also makes a strong case with his explosive talent, while Derrick Henry, now with the Baltimore Ravens, continues to demonstrate high-level performance despite age concerns. In the second and third tiers, players like Josh Jacobs and De'Von Achane are highlighted for their potential to contribute significantly to fantasy rosters, albeit with some role-related uncertainties. As the 2025 drafts approach, targeting these top talents will be crucial for success.