Week 2 RB rankings for 2025 center on McCaffrey at the top, with Bijan Robinson, Saquon Barkley, Jahmyr Gibbs and Josh Jacobs in a tight first tier. The next wave leans on Kyren Williams, Breece Hall, Jonathan Taylor, De'Von Achane, James Cook and De'Von Achane, plus Ashton Jeanty and Bhayshul Tuten stepping into larger roles as trades and injuries unfold. Ekeler’s Week 2 status adds a layer of uncertainty for lineups, especially in PPR formats.

News notes shape decisions: Jaydon Blue expected inactive, Jordan Mason and Aaron Jones split early work in Minnesota, Tuten could grab a bigger slice post‑Bigsby deal, and Najee Harris might see a modest uptick in Week 2. Managers should prioritize workload, pass-catching upside, and early-week intel to navigate the Week 2 slate.