Five bold Week 2 predictions for Denver vs. Indianapolis shape a fantasy-friendly path: a 200+-yard rushing onslaught with one back eclipsing 100 yards; Bo Nix climbs to 70% completions with 200 passing yards, a touchdown and no interceptions, while the offense emphasizes the run early. Denver’s defense eyes a six-sack performance from different players, including a secondary contributor, plus three takeaways. Jeremy Crawshaw bumps to a 49.5-yard punt average on a handful of tries, while Payton’s plan leans into ball control and field-position leverage.

The Colts’ run defense is vulnerable, even as their pass defense shines; if Denver can sustain the ground game, the game plan should unlock better efficiency for Nix and keep the chains moving. The piece uses a Giants scenario to illustrate pressure-induced turnovers, underscoring how the Broncos’ defense and special teams could swing outcomes in a close contest. For fantasy bettors, focus on the running back workload, Nix’s efficiency, sack distribution, and Crawshaw’s punting windows.

New England trades Ja’Lynn Polk to New Orleans and promotes Kobee Minor and Mark Robinson from the practice squad. Polk, a 2024 second-rounder, logged 12 catches for 87 yards and 2 TDs in 15 games before a shoulder injury ended his rookie season. Minor (Memphis, 2025 seventh-round) and Robinson (Pittsburgh, 2022 seventh-round) join as active players as NE heads to Miami for a pivotal Sunday matchup.

The Saints acquire Polk to bolster their WR corps, while New England leans on depth pieces on defense and special teams heading into the clash with the Dolphins at Hard Rock Stadium Sunday at 1 p.m.

Miami's right side is in flux as Austin Jackson lands on IR and James Daniels joins him, forcing a reshaped O-line for at least four games. Borom steps in at right tackle with Kion Smith sliding to right guard; Strange, Brunskill or Lamm may inherit later opportunities. Waller remains in the lineup with a two-TE look, and Wilson Jr. plus Patterson get practice-squad elevations to stay ready. Cornell Armstrong moves up to fifth cornerback as Bonner sits, while Wright is doubtful and Waller stays active.

Depth and tempo become the x-factors: the Dolphins will lean on internal depth, situational protection schemes, and occasional run-game adjustments against a brutal early schedule (Patriots, Bills, Jets, Panthers). The earliest Jackson or Daniels could return is Week 6 vs Chargers, giving Miami a light at the end of the tunnel as Eichenberg works off PUP. Fantasy angles hinge on who seizes the opportunistic reps along the line and how the TE and RB options are deployed in the shift.