Week 3 fantasy outlook centers on Bills-Dolphins Thursday night, with Khalil Shakir trying to rebound after a quiet week and the Miami trio of Tua Tagovailoa, Tyreek Hill, and Jaylen Waddle shaping the pass game. Dalton Kincaid and James Cook offer Bills upside, while Josh Allen legs into another high-ceiling matchup. De'Von Achane is a high-volume back, and Joshua Palmer provides a steady Bills secondary option. The Who Should I Start tool helps compare up to four players for precise start decisions.

Buffalo hosts Miami on Thursday Night Football in Week 3, riding a 2-0 start and a 9-0 home record vs the Dolphins (including playoffs). The spread sits at -12 for Buffalo with an over/under of 50, reflecting Buffalo's high-scoring offense and Miami's improving attack. Expect Josh Allen to exploit a Dolphins run defense that underwhelmed early, while Miami looks to sustain its improved passing and De'Von Achane's big-play potential.

Fantasy angles center on James Cook in a favorable matchup, Tyreek Hill and Jaylen Waddle against a stingy Buffalo secondary, and Tua Tagovailoa's efficiency against Buffalo's historical struggles. The SportsLine model leans over the total and picks Buffalo to cover, guiding bets and lineup decisions for a marquee Week 3 clash.

Top wideouts by PFF receiving grade through Week 2 of 2025 showcase a mix of elite playmakers and breakout rookies. Puka Nacua is policing the slot and earning repeated targets, Amon-Ra St. Brown engineered a standout Week 2, while Tetairoa McMillan posted a premier rookie debut and looks like a sustained threat. Garrett Wilson’s Week 1 efficiency and Tyreek Hill’s big-play profile anchor the upper echelon, with Ja'Marr Chase and CeeDee Lamb leading the strong core behind them.

The field also features a mix of proven veterans and emerging talents—Zay Flowers, Jaxon Smith-Njigba, Malik Nabers, and others—whose target shares, yards after catch, and separation grades hint at persistent fantasy upside despite variable game plans. The data underlines the value of slot vs outside targets, press coverage, and open separation in driving fantasy points and weekly ceilings.

Week 3 kickoff features Bills vs. Dolphins as the marquee opener, with two high-powered offenses expected to push the pace and fantasy scores. The 16-game slate centers on division battles, star matchups, and injury news that will shape start/sit calls and DFS lineups throughout the weekend.

Tools and projections from PFF guide the edge battles, run defenses, and pass-blocking duels that fantasy managers chase. Expect tight ends and backfields to factor in strong ways as teams navigate a short week and pivotal early-season tests.