Three game-defining clashes loom in Colts-Dolphins Week 1: Zach Sieler vs Indianapolis interior blockers, Jonathan Taylor powering the Colts on the ground, and De'Von Achane with Miami's speed backfield testing Indy’s run defense and opening big-play chances for Tyreek Hill and Jaylen Waddle. Success hinges on Colts’ interior protection and Taylor’s burst, while Miami’s run-driven approach can tilt the fantasy lens toward Achane and the Dolphins’ receivers.