The New York Giants are set to face off against the Buffalo Bills, and this matchup is significant for fantasy football enthusiasts as it showcases several key position battles. The Giants will highlight the performance of quarterback Daniel Jones, who aims to build on his previous season, enhanced by the addition of Darren Waller, a pivotal tight end acquisition expected to bolster the passing game. The running back situation also needs attention, with Saquon Barkley looking to reclaim his top form after injuries hampered his past seasons.

On the defense side, the Giants will rely on Azeez Ojulari and Kayvon Thibodeaux to apply pressure on the Bills’ offense, led by Josh Allen. The Bills, while boasting a solid offensive lineup, will test the Giants' revamped defense. A particular focus will be on the receiver corps, where Stefon Diggs and Gabe Davis will be under scrutiny to produce against a formidable Giants secondary. This game is crucial for both teams as they refine their rosters ahead of the regular season, making it a key observation point for fantasy managers.