Week 3 brings Seattle as 7.5-point favorites at home against New Orleans, but injuries to Devon Witherspoon and Nick Emmanwori could blunt Seattle’s secondary edge. Spencer Rattler and the Saints offense have found traction, and the SportsLine model assigns a 38% upset chance for New Orleans—a surprisingly credible figure for a road test. The model’s Week 3 survivor pick diverges from Seattle, suggesting a one-score outcome with Seattle at about 62% win probability.

The slate features seven 5+ point spreads, including Dolphins-Bills, Packers-Browns, Falcons-Panthers, Jets-Bucs, Saints-Seahawks, Chiefs-Giants, and Lions-Ravens, underscoring how survivor players will chase value. The model touts a long, earned track record (10,000 simulations, 37-17 on top picks since 2024) and is the guiding beacon for those locking Week 3 picks, with promos noted for new users.

Josh Simmons illness kept him limited in practice as KC prepared for Week 3 against the New York Giants; status could go either way, with the Chiefs hopeful he plays. If he can’t go, Wanya Morris or Jaylon Moore would slide in at left tackle, testing KC’s protection and potentially shifting the run-pass balance.

Fantasy managers should monitor updates, as LT stability can swing Mahomes’ timing, the play-action game, and Isiah Pacheco’s rushing lanes in a pivotal matchup.

Jalen Royals is listed with knee tendinitis and has missed the first two Chiefs games, with a Wednesday limited practice keeping his Week 3 status uncertain against the Giants. If he’s sidelined, Kansas City’s WR corps gets a clearer path to targets.

In that scenario, Hollywood Brown and JuJu Smith-Schuster become the primary options, while Tyquan Thornton and Nikko Remigio could soak up additional routes and snaps. Fantasy managers should monitor practice updates closely and anticipate increased volume for the Chiefs’ top veterans in a challenging Week 3 matchup.