In the 2025 fantasy football landscape, certain running backs are shaping up as potential busts, making them less desirable picks as drafts approach. Joe Mixon of the Houston Texans, once a top option, has shown signs of decline, particularly in the latter part of last season where he struggled to find the end zone. His age and the team's offensive challenges diminish his value. Likewise, Kenneth Walker III's potential is hampered by injury history and the emergence of Zach Charbonnet, suggesting a possible committee approach in Seattle.

Najee Harris has landed in a similar situation after signing with the Los Angeles Chargers. His future looks uncertain with rookie Omarion Hampton on the roster, likely reducing his production. Tyrone Tracy Jr. of the New York Giants is also at risk due to a recent draft pick, Cam Skattebo, which threatens his starting role. Lastly, Travis Etienne Jr. faces a crowded backfield in Jacksonville, with Tank Bigsby and new talent Bhayshul Tuten potentially eating into his opportunities. Targeting safer options or rookies might be wiser for savvy fantasy players.