Aaron Jones is out four weeks after going on IR with a hamstring injury, shifting major early-season workload to Jordan Mason in a new every-down role. Austin Ekeler is done for the year with an Achilles tear, leaving Washington Commanders’ backfield trio of Jacory Croskey-Merritt, Chris Rodriguez Jr., and Jeremy McNichols to absorb volume. Tyjae Spears could return in Week 5, giving Tennessee a much-needed boost behind Tony Pollard’s workload. Jaylen Wright is a strong bet to debut for Miami against Buffalo if cleared, while Rasheen Ali is sidelined by a concussion and Keaton Mitchell looms as the Ravens’ next specialist option. Kyle Juszczyk’s concussion further thins San Francisco’s blocking defense, joining George Kittle and Brock Purdy on the injury report. In short, backfields across the league are in flux heading into Week 3.

Specify your lineups with an eye on pass-catching upside and changing handcuff dynamics: Mason for immediate RB2–flex value, Croskey-Merritt and Rodriguez Jr. sharing volume in Ekeler’s absence, and Mitchell nudging into meaningful snaps if Ali remains out. Spear’s return would immediately restore Titans’ backfield depth, while Wright’s status could unlock Dolphins’ late-week upside against Buffalo for fantasy rosters in need of a boost.