McCaffrey's Week 1 status drives the 49ers' backfield chess—if healthy, he remains the workhorse, and Robinson and Guerendo are deep-league lotto tickets. If McCaffrey is scratched, Robinson becomes a strong Week 1 start, with Guerendo pairing upside as a TD-heavy flex. In standard leagues Guerendo edges as a dart-throw; in PPR, Robinson's passing-down role gives him the edge. Shanahan's RB-by-committee means both could pop in deeper formats, especially if CMC is limited.

With McCaffrey’s calf uncertainty resolved by Schefter as active, the article leans Robinson as the safer PPR option and Guerendo as the upside play in TD-heavy setups. The San Francisco backfield remains volatile, but Week 1 expectations tilt toward McCaffrey handling most duties, leaving Robinson as the clearer Week 1 anchor and Guerendo as a speculative add for deeper pools.