Six Week 1 WR/CB pairings shape fantasy lineups, with three to target and three to dodge. Emeka Egbuka projects as a WR2 for TB against Atlanta’s weaker corner group, while Tee Higgins draws a high-volume, favorable matchup for Cincinnati against Cleveland’s depleted perimeter corps. Marvin Mims Jr. has big upside for Denver versus a Titans secondary with exploitable coverage. Conversely, DK Metcalf could face shadowed sales against Sauce Gardner, Tutu Atwell against Jalen Pitre, and Wan’Dale Robinson versus Mike Sainristil, making benching prudent in some formats.

Injury and game-script context—Week 1’s high o/u and Denver’s pass-friendly pace, plus New York’s aggressive man schemes—amplify the volatility. The piece highlights how preseason grades, target rates, and YPRR metrics inform start/sit calls and DFS exposure, guiding savvy managers through week one’s thin margins.