The San Francisco 49ers, defending NFC champions, face a challenging schedule as they play four teams coming off a bye week. This includes tough matchups against the Seattle Seahawks, Kansas City Chiefs, and Dallas Cowboys in a three-week stretch. The 49ers also take on the Buffalo Bills, another team coming off their bye, in what could be their toughest game.

Meanwhile, twelve teams, including the Buffalo Bills, Philadelphia Eagles, New England Patriots, and Green Bay Packers, won't face any opponents coming off a bye week in 2024.