The Baltimore Orioles face a significant challenge as first baseman Ryan Mountcastle is set to miss extended time due to a right hamstring injury. Interim manager Tony Mansolino has suggested that Mountcastle, who was placed on the injured list after undergoing an MRI, could be sidelined indefinitely, although no specific timetable has been given. This absence leaves a considerable gap in the Orioles' lineup, as Mountcastle has contributed with a .264 batting average, 10 home runs, and 34 RBIs in 58 games this season.

In response to Mountcastle's injury, the Orioles have called up Coby Mayo from Triple-A Norfolk, giving him a clear opportunity for regular at-bats, either at first base or as the designated hitter. Ryan O'Hearn is also expected to take on a larger role at first base. This situation marks a challenging moment for the Orioles, who are already managing a roster with 12 players on the injured list, including outfielder Cedric Mullins, who recently joined Mountcastle on the IL.