Wednesday's main slate of 10 MLB games starts at 7:07 pm ET, with a 1:05 pm early slate also on tap. The night centers on a pitcher-friendly environment, led by premium arms and a solid value tier. Framber Valdez and Sonny Gray headline the stud targets, with Gray favored by form and matchup against Pittsburgh. Eric Lauer and rookie Ryan Bergert offer salary relief with quality upside, while Carmen Mlodzinski and Bubba Chandler present upside bets if they can push through innings.

Offense leans into ordered stacks: Seiya Suzuki and George Springer anchor price-conscious Cubs and Blue Jays cores, respectively. The Texas Rangers pop as the clearest stack (Josh Smith, Wyatt Langford, Corey Seager) even with Semien out, while the Astros—Jeremy Peña, Jose Altuve and Christian Walker—shape a tight mini-stack against the Rockies. Add value bats like Pavin Smith and Royals options, and stay alert for late-breaking lineup news.

Three breakout arms drive Week 22 fantasy chatter: Cade Horton has flipped his Cubs arc, delivering a 1.11 ERA and 0.90 WHIP over his last nine starts, backed by a slider and changeup carrying elite swing-and-miss and a sinker that trims contact. Jack Leiter’s surge features a premium 97 mph fastball and a strong changeup, yielding a 2.86 ERA across ten starts, though walk rates keep WHIP higher than ideal. Nolan McLean’s ground-ball mastery and five-pitch mix add depth in deeper leagues, with upside if he can tighten control.