The MLB action heats up with a full slate of games, offering opportunities for savvy bettors focusing on No Runs First Inning (NRFI) picks. Key matchups on June 20, 2025, feature solid pitching duels that enhance the potential for scoreless first innings. Notable matchups include Tomoyuki Sugano facing Max Fried, Blade Tidwell against Zack Wheeler, Michael Lorenzen squaring off with Nick Pivetta, and Hunter Dobbins challenging Hayden Birdsong.

One of the highlights is the matchup between the Baltimore Orioles and the New York Yankees. Sugano's recent form, including a previous outing where he dominated the Yankees with five scoreless innings, presents a favorable scenario for an NRFI bet. Similarly, Fried's stellar 1.89 ERA underlines the Yankees' struggles against left-handed pitchers, making this a compelling pick.

In the game featuring the New York Mets against the Philadelphia Phillies, Wheeler's impressive stats complement Tidwell's potential, especially with the former boasting a 2.76 ERA. The familiarity gap could benefit Tidwell, making this match another NRFI target. The Kansas City Royals and San Diego Padres matchup also looks promising with Lorenzen's effective start against Pivetta's strong home performance.

Lastly, the Boston Red Sox face the San Francisco Giants, where both pitchers have shown an ability to limit early scoring opportunities. Given the favorable odds across these matchups, bettors should keep an eye on weather and lineups before placing wagers.