As the 2025 MLB season kicks off, identifying two-start pitchers for your fantasy roster becomes critical. Drew Rasmussen stands out against the Pirates and Rangers, boasting elite numbers and should be a must-start. Bowden Francis, despite a lackluster Grapefruit League, shows promise in his matchups against the Nationals and Mets. Ronel Blanco remains a reliable option against decent offenses, while Cade Povich's solid spring gives him potential against the Red Sox and Royals. Chris Paddack's health and strikeout ability against the White Sox make him a risk worth taking, and Martín Perez's historical early-season success could pay dividends, although he remains a gamble.

The National League features Corbin Burnes against the Yankees and Nationals, and Tyler Glasnow is unbenchable despite tough matchups. Cristopher Sánchez is an automatic start, while Grant Holmes and Ben Brown present mixed prospects for deeper leagues. Finally, Brady Singer's performance with the Reds and Brewers could yield valuable results, making him a solid option in most formats.