Boston Red Sox experienced a gut-wrenching 7-6 defeat against the Toronto Blue Jays in extra innings despite leading 6-0 at one point. The Red Sox's Garrett Whitlock struggled in the seventh, giving up a game-tying three-run homer to Anthony Santander. In the 10th inning, Toronto's Jeff Hoffman shut down Boston, striking out Alex Bregman and Trevor Story. Blue Jays clinched the win with Alejandro Kirk's walk-off single, sending Vladimir Guerrero Jr. home.

Lucas Giolito had a solid debut for the Red Sox, allowing three runs and striking out seven over six innings, though he faltered in the sixth with back-to-back homers. Carlos Narváez contributed significantly with a two-run blast that initially put Boston ahead. The series finale is set for Thursday night, featuring Boston's Tanner Houck against Toronto's José Berríos.