On July 22, 2025, MLB betting enthusiasts can look forward to several engaging NRFI (No Runs First Inning) betting opportunities across a packed schedule. Matchups feature standout pitchers like Casey Mize and Mitch Keller, who are both having solid seasons, making their NRFI odds appealing. Mize, with an impressive 3.15 ERA, and Keller, at 3.48, are expected to perform well against struggling offenses.

In particular, the Detroit Tigers have been ineffective at scoring early, notching only 29 runs in July so far. The Boston Red Sox and Philadelphia Phillies, featuring Richard Fitts and Cristopher Sánchez, also present favorable conditions for NRFI betting, given their recent first-inning struggles. Meanwhile, the Milwaukee Brewers, riding a winning streak, face the Seattle Mariners and their lackluster first-inning performance. The Yankees and Royals matchup draws attention for its potential over/under given the pitchers involved. Overall, July 22 offers plenty of NRFI betting angles worth considering amidst solid pitching matchups and low-scoring trends.