The Chicago White Sox and Detroit Tigers are set to clash at Comerica Park in Detroit on April 4, 2025, for the first game of their weekend series. Both teams are struggling, each holding a 2-4 record. The White Sox recently faced the Minnesota Twins, losing two of three games, while the Tigers managed to win two out of three against the Mariners after a loss on Wednesday.

Jonathan Cannon will pitch for Chicago, boasting a flawless 0.00 ERA from his first start, while Detroit's Jack Flaherty comes in with a respectable 3.18 ERA. Betting trends suggest the Tigers are favored with a -1.5 spread, leading to intriguing matchup dynamics for bettors and fantasy players alike.