In a lopsided matchup, Sean Burke struggled on the mound for the Chicago White Sox, suffering a 10-2 defeat against the Houston Astros. Burke allowed a career-high seven runs over 3 2/3 innings, highlighted by Christian Walker's two-run homer in the first inning. Despite Burke’s pre-game confidence about his physical condition, he admitted to making critical mistakes that the Astros capitalized on. Walker continued to shine, adding a two-out double to drive in additional runs, while Burke's inability to effectively mix pitches led to early troubles.

Meanwhile, Astros starter Ryan Gusto limited the White Sox to just two runs and struck out seven batters, showcasing strong command over his pitches. The White Sox's lineup managed only two runs, with contributions from Mike Tauchman and Miguel Vargas, but overall struggled against Gusto’s precision. Owen White, in his debut, provided some relief but couldn’t prevent the damage from escalating. The game illustrated a stark contrast in pitching effectiveness between Gusto's performance and Burke's missteps, leaving the White Sox searching for answers as they faced a strong Astros lineup.