The Arizona Diamondbacks are squaring off against the Chicago White Sox in Chicago on June 23, 2025. Arizona, currently at 39-38, is looking to bounce back after a 4-2 loss to Colorado, although they previously won three straight games, scoring a total of 28 runs. This match is part of a nine-game road trip for the Diamondbacks, which began in Toronto. Meanwhile, the 25-53 White Sox are coming off a successful series against the Blue Jays, winning two of three games. Tonight's matchup features Arizona's Eduardo Rodriguez (2-4, 5.93 ERA) against Chicago's Shane Smith (3-4, 2.85 ERA).

Betting odds favor the Diamondbacks slightly at -129 on the moneyline, while the White Sox sit at +109. Recent trends indicate that the Diamondbacks have performed well away against teams with losing records, winning 12 of their last 20 in such matchups. On the opposing side, the White Sox have struggled, losing 9 of their last 11 games. Expert predictions suggest a potential play on the over for the game's total, set at 8 runs.