The Houston Astros struggled once more as their starter Ryan Gusto faced a barrage from the Kansas City Royals, who scored seven runs in the first three innings, ultimately securing a 7-5 victory at Daikin Park. Gusto, in his fifth major-league appearance, allowed seven runs with only seven outs, leaving the team with an uphill battle. Although the Astros rallied with a three-run eighth inning, they fell short despite bringing the tying run to the plate in the ninth.

Michael Wacha effectively shut down the Astros' offense for most of the game, working six scoreless innings. Houston's offense has continued to struggle with runners in scoring position, exemplified by a critical double play when they had the bases loaded. The game marked a taxing stretch for the Astros, needing to rely heavily on their bullpen as they entered a grueling schedule of 17 games in 17 days.