Heading into Week 16 of the 2025 fantasy baseball season, several prominent players are struggling, causing significant concern for fantasy managers. Zac Gallen of the Arizona Diamondbacks, once a reliable ace, now sits with a disappointing 5.40 ERA, prompting discussions on whether to hold or drop him. Drew Rasmussen from the Tampa Bay Rays has seen his innings limited, making him a candidate to sell as well. Nolan Arenado's recent dip, coupled with ongoing injury issues, suggests a sell strategy is wise as he continues to underperform. Meanwhile, Tommy Edman and Logan O'Hoppe are also under scrutiny, with Edman’s injury and O'Hoppe's inconsistency leading to suggestions to drop them in many formats.