Teoscar Hernández showcased his power with a three-run homer, putting the Dodgers ahead against Tarik Skubal and the Tigers in the fifth inning. Hernández, who set a personal record with 33 homers last season, proved he's still a force. In contrast, Nolan Arenado rebounded from a tough season, hitting a significant home run for the Cardinals against the Twins, suggesting he's ready to reclaim his former glory. Meanwhile, Victor Scott II made an exceptional catch for St. Louis, while the Marlins achieved a dramatic walk-off victory to end a four-year Opening Day losing streak.

The Giants rallied late to defeat the Reds, highlighted by Wilmer Flores' three-run blast that brought them triumph. The White Sox managed a winning start, currently above .500 for the first time in a year. Adley Rutschman of the Orioles hit two home runs in a strong performance as Baltimore outclassed their opponents. Bryce Harper's timely homer tied the game for the Phillies, who later took the lead, showcasing their offensive firepower. The pitching highlight was MacKenzie Gore's impressive 13-strikeout performance for the Nationals, marking a franchise record for Opening Day.