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August 15, 2025
Yankees vs. Cardinals Prediction, Odds, Probable Pitchers and Prop Bets for Friday, Aug. 15
Iain MacMillan
Sports Illustrated
Yankees vs. Cardinals Prediction, Odds, Probable Pitchers and Prop Bets for Friday, Aug. 15

Interleague action kicks off at Busch Stadium as the New York Yankees visit the St. Louis Cardinals in a weekend showdown that could shape both clubs’ momentum. New York carries a 0.5 game lead for the final wild-card berth and sits 6.5 games behind the Blue Jays in the AL East, pressing for a win to pivot their postseason push. Caesars lists the Yankees as -135 on the moneyline with a -1.5 run line and a total of 9. A notable betting angle is Andre Pallante over 2.5 walks allowed, a plus-money prop that leverages the Yankees high walk rate this season.

The Cardinals have scuffled offensively, ranking dead last in OPS since the All-Star break at .661, while the Yankees sit around .707 OPS, making this an edge-lite series with NYY favored to take the opener. The matchup features Luis Gil for New York and Pallante for St. Louis, presenting a contrast in early-season results and bullpen utilization that could determine who seizes early weekend control.

Fantasy and DFS angles center on Pallante’s walk-prone profile; if the Cardinals pitcher issues free passes, the Yankees’ patient approach could yield extra-base hits and RBI opportunities. Gil’s season has been tumultuous, but upside remains given the matchup against a patient lineup. The game environment favors a controlled Yankees effort with a tested bullpen to close it out, barring late-inning hiccups.

Which angle stands out most for tonight's Yankees vs. Cardinals game from a fantasy betting view?What is the safest cashing path if you’re betting on the Yankees to win this opener?If you could only pick one player to target fantasy-wise in this game, who would it be?How should bettors view the total and run line given the pitching matchup and offensive splits?
Mentions:
@Andre Pallante | St. Louis Cardinals | MLB
@Andre Pallante | St. Louis Cardinals | MLB
@Luis Gil | New York Yankees | MLB
@Luis Gil | New York Yankees | MLB
New York Yankees | MLB
New York Yankees | MLB
St. Louis Cardinals | MLB
St. Louis Cardinals | MLB

https://www.si.com/betting/yankees-vs-cardinals-pr..

New York Yankees:
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Brent Headrick (0)
Gerrit Cole (901)
Jake Cousins (54)
Yerry de los Santos (1)
Luis Gil (239)
Mark Leiter Jr. (54)
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