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August 16, 2025
Yankees vs. Cardinals Prediction, Odds, Probable Pitchers and Prop Bets for Saturday, Aug. 16
Iain MacMillan
Sports Illustrated
Yankees vs. Cardinals Prediction, Odds, Probable Pitchers and Prop Bets for Saturday, Aug. 16

Interleague action at Busch Stadium features a critical chase for the AL wild-card. The New York Yankees visit the St. Louis Cardinals in a prime fantasy matchup, with the Yankees positioned as road favorites and a -1.5 run line, while the total sits at 7.5. The betting narrative centers on Max Fried for New York and Sonny Gray for St. Louis, offering a pitching clash that could flip late in the game as bullpens heat up. Cody Bellinger is highlighted in a top prop (OVER 1.5 total bases) and is portrayed as a key catalyst to back or fade depending on ownership and lineup flexibility.

The card leans toward the Bronx Bombers with offensive momentum and a Cardinals squad that’s struggled OPS-wise since the All-Star break, creating an atmosphere ripe for streamers and DFS players to chase upside in a tightly contested, interleague grind. The piece also nods to a Walk-Off Wagers-backed stance on New York, emphasizing bullpen leverage and late-inning outs as tiebreakers in a game that could hinge on a timely hit or a missed opportunity by St. Louis.

For fantasy managers, the core angles are straightforward: target Bellinger in dfs if the matchup aligns, monitor Fried’s ability to mix velocity and command, and weigh Yankees stack potential if the ball travels well off Gray. Price and bullpen usage could swing the outcome, so late lineup tweaks and weather updates will matter before lock.

Which side has the clearer path to value in this Yankees-Cardinals interleague clash?What prop and lineup combo could maximize daily fantasy upside in this game?How does this game influence season-long or daily fantasy projections for the Yankees?If you had to pick one sleeper from the Cardinals, who offers the best upside in this matchup?
Mentions:
Boston Red Sox | MLB
Boston Red Sox | MLB
@Cody Bellinger | New York Yankees | MLB
@Cody Bellinger | New York Yankees | MLB
@Max Fried | New York Yankees | MLB
@Max Fried | New York Yankees | MLB
New York Yankees | MLB
New York Yankees | MLB
@Sonny Gray | St. Louis Cardinals | MLB
@Sonny Gray | St. Louis Cardinals | MLB
St. Louis Cardinals | MLB
St. Louis Cardinals | MLB
Toronto Blue Jays | MLB
Toronto Blue Jays | MLB

https://www.si.com/betting/yankees-vs-cardinals-pr..

New York Yankees:
Braden Shewmake (0)
Brent Headrick (0)
Gerrit Cole (901)
Jake Cousins (54)
Yerry de los Santos (1)
Luis Gil (239)
Mark Leiter Jr. (54)
Carlos Rodon (657)
Clarke Schmidt (1)
Marcus Stroman (1)
Luke Weaver (282)
J.C. Escarra (10)
Austin Wells (1)
Oswaldo Cabrera (272)
Jazz Chisholm Jr. (4)
Anthony Volpe (1)
Jasson Dominguez (5)
Trent Grisham (268)
Aaron Judge (1)
Giancarlo Stanton (1006)
Manager Aaron Boone (1)
Jose Caballero (5)
Michael Arias (0)
Cody Bellinger (209)
Fernando Cruz (17)
Devin Williams (151)
David Bednar (3)
Allan Winans (1)
Ryan McMahon (11)
Camilo Doval (0)
JT Brubaker (4)
Carson Coleman (1)
Scott Effross (0)
Ian Hamilton (0)
Will Warren (12)
Jesus Rodriguez (0)
DJ LeMahieu (12)
Ben Rice (10)
Jorbit Vivas (1)
Everson Pereira (0)
Max Fried (41)
Jonathan Loaisiga (5)
Paul Goldschmidt (1)
Cam Schlittler (24)
Amed Rosario (0)