On July 21, the San Diego Padres (54-45) face off against the Miami Marlins (46-52) at LoanDepot Park. Randy Vásquez will pitch for the Padres, while Eury Pérez gets the nod for the Marlins. Both teams had a strong start to the second half of the season, winning their respective series against the Nationals and Royals. This matchup marks their second series of the season, with the Padres having previously taken two of three games against Miami in San Diego, but the Marlins won the last game of that series, 10-8.

The Padres are on a nine-game East Coast road trip, starting with three games against the Nationals before heading to face the Marlins and then the Cardinals. Their remaining schedule includes favorable matchups that could position them for a postseason push. Recent trends indicate that the Padres are 12-7 in games started by Vásquez this season, while the Marlins are 5-2 with Pérez on the mound. Betting insights suggest leaning towards the Padres at +1.5 and the over on a total of 8.0 runs.