The Detroit Tigers face off against the St. Louis Cardinals today, May 21, 2025, in what promises to be an exciting matchup after the Tigers leveled the series with a thrilling 5-4 victory last night. Starting pitcher Brant Hurter (1-0, 2.35 ERA) will take the mound for Detroit against Cardinals’ Andre Pallante (4-2, 4.11 ERA). Key players to watch include Tigers' Riley Greene, who delivered a game-winning RBI double in last night's contest.

As the teams prepare for the 1:15 PM EST game at Busch Stadium, the latest betting odds show the Tigers slightly favored at -104 on the moneyline while the Cardinals sit at -112. With the total set at 8.0 runs and the spread at 1.5, experts are leaning toward the Tigers to cover the spread and the over on the total runs, citing their strong recent performances against National League teams.