The St. Louis Cardinals have made strategic moves in the 2025 MLB Draft, starting with their first pick, Liam Doyle, a pitcher from Tennessee, selected 5th overall. Following Doyle, the Cardinals continued to lean on talent from Tennessee, adding Ryan Mitchell from Houston High School and Tanner Franklin, a fellow pitcher, showcasing a clear focus on strengthening their pitching lineup.

The draft spans over 20 rounds, with a total of 21 selections for the Cardinals, indicating a robust approach to enhancing their farm system. Players like Cade Crossland and Ethan Young will also play vital roles in the Cardinals' future, potentially impacting their High-A affiliate, the Peoria Chiefs.