On this Wednesday, a pair of intriguing National League matchups dominate the MLB betting landscape. The San Francisco Giants take on the San Diego Padres, where pitchers Landen Roupp and Michael King are set to duel. Roupp's 4.56 ERA is overshadowed by his impressive metrics, including a notable 10.9 K/9 rate. While he has had a shaky start, his ability to limit runs in most outings is promising. King's stellar 2.18 ERA and low WHIP suggest he will be a tough challenge for the Giants. Given both pitchers' strong early-game performances, betting on the 'Under' for runs in the first few innings seems prudent.

In the evening, the St. Louis Cardinals face the Cincinnati Reds with Steven Matz and Andrew Abbott on the mound. Matz's recent form shows promise, but historical struggles against Reds batters raise concerns. Abbott’s solid start to the season indicates he can limit the Cardinals' offense, especially given their struggles against left-handed pitching. The Reds are favored to score high, making their first-five innings line appealing for bettors.