On June 10, 2025, the Toronto Blue Jays and St. Louis Cardinals, both with identical records of 36-30, faced off at Busch Stadium. Chris Bassitt (6-3, 3.56 ERA) was on the mound for Toronto, showcasing a strong recent performance against the Philadelphia Phillies. The Blue Jays came off a thrilling 5-4 victory in extra innings, thanks to Alejandro Kirk's clutch double. The Cardinals countered with Miles Mikolas (4-2, 3.96 ERA), who struggled in his last home outing. Betting odds favored the Blue Jays slightly at -126 on the moneyline, while the total was set at 8.0 runs.

Recent trends showed the Blue Jays excelling on the road against winning teams, with a record of 4-1 in their last five away games. The Cardinals, with Mikolas on the mound, had a respectable 3.99 ERA over his past five starts at home. Expert analysis leaned towards the Blue Jays for the moneyline, while indicating a potential cover for the Cardinals at +1.5. Overall, the matchup promised to be competitive, with both teams looking to solidify their playoff positions.