Three top MLB homer picks headline today’s fantasy-friendly haul: Josh Lowe at +560, Lenyn Sosa at +475, and Corey Seager at +290. Lowe targets Miles Mikolas in a Rays–Cardinals clash, aiming to snap a homerless lull this season. Sosa, White Sox slugger, eyes Zebby Matthews and another round of big flies after leading his club in long balls. Seager stacks the Rangers’ power against Slade Cecconi, a setup that invites a value pop for bold DFS lineups.

Each pick hinges on matchup dynamics and recent power trends. Mikolas has ceded homers at a notable clip, Tucker-friendly Rays home park factors, and Lowe’s steady proximity to the plate all contribute to the bet. Sosa’s slugging pace and Matthews’ HR-prone profile set up a duel for the 18th round-tripper, while Cecconi’s HR-rate vulnerability is a clear invitation for Seager to connect and drive a run-scoring swing.

Stay sharp on line movement and park quirks as the weekend unfolds, and chase these Three for a weekend bankroll boost with a savvy, structured approach to risk and reward.