On April 16, the Boston Red Sox (9-10) will face off against the Tampa Bay Rays (8-9) at George M. Steinbrenner Field as they continue their series after a 7-4 victory for Boston in the previous game. Alex Bregman had a standout performance, going 5-5 with two home runs. Tonight's pitching matchup features Sean Newcomb, who is struggling with an 0-2 record and a 4.97 ERA, against Zack Littell, who has yet to secure a win this season with an unfortunate 0-3 and a 6.88 ERA.

The betting odds currently favor the Rays at -143 on the moneyline, with Red Sox at +121. Oddsmakers set the total runs at 9.0. Analytics suggest a lean towards the Rays for a moneyline bet, while the Red Sox may cover the spread at +1.5. Notably, Tampa Bay has struggled on the Run Line this season (6-11), and their recent games have frequently gone over the total.